The Vestigial Esterase Domain of Haemagglutinin of H5N1 Avian Influenza A Virus: Antigenicity and Contribution to Viral Pathogenesis

The Vestigial Esterase Domain of Haemagglutinin of H5N1 Avian Influenza A Virus: Antigenicity and Contribution to Viral Pathogenesis

Initial attempts to develop monoclonal antibodies as therapeutics to resolve influenza infections focused mainly on searching for antibodies with the potential to neutralise the virus in vitro with classical haemagglutination inhibition and microneutralisation assays. This led to the identification...

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Bibliographic Details
Main Authors: Zhiqiang Zheng, Subha Sankar Paul, Xiaobing Mo, Yu-Ren Adam Yuan, Yee-Joo Tan
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Vaccines
Subjects:
influenza
neutralising antibodies
vestigial esterase
antibody dependent cell-mediated cytotoxicity
pH-induced conformational changes
Online Access:http://www.mdpi.com/2076-393X/6/3/53

Internet

http://www.mdpi.com/2076-393X/6/3/53

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