Gut-derived acetate promotes B10 cells with antiinflammatory effects

Gut-derived acetate promotes B10 cells with antiinflammatory effects

Autoimmune diseases are characterized by a breakdown of immune tolerance partly due to environmental factors. The short-chain fatty acid acetate, derived mostly from gut microbial fermentation of dietary fiber, promotes antiinflammatory Tregs and protects mice from type 1 diabetes, colitis, and alle...

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Bibliographic Details
Main Authors: C.I. Daïen, J. Tan, R. Audo, J. Mielle, L.E. Quek, J.R. Krycer, A. Angelatos, M. Duraes, G. Pinget, D. Ni, R. Robert, M.J. Alam, M.C.B. Amian, F. Sierro, A. Parmar, G. Perkins, S. Hoque, A.K. Gosby, S.J. Simpson, R.V. Ribeiro, C.R. Mackay, L. Macia
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-04-01
Series:JCI Insight
Subjects:
Immunology
Metabolism
Online Access:https://doi.org/10.1172/jci.insight.144156

Internet

https://doi.org/10.1172/jci.insight.144156

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