Rosiglitazone promotes ENaC-mediated alveolar fluid clearance in acute lung injury through the PPARγ/SGK1 signaling pathway

Rosiglitazone promotes ENaC-mediated alveolar fluid clearance in acute lung injury through the PPARγ/SGK1 signaling pathway

Abstract Background Pulmonary edema is one of the pathological characteristics of acute respiratory distress syndrome (ARDS). The epithelial sodium channel (ENaC) is thought to be the rate-limiting factor for alveolar fluid clearance (AFC) during pulmonary edema. The peroxisome proliferator-activate...

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Bibliographic Details
Main Authors: Jing He, Di Qi, Xu-mao Tang, Wang Deng, Xin-yu Deng, Yan Zhao, Dao-xin Wang
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Cellular & Molecular Biology Letters
Subjects:
Acute lung injury
Alveolar epithelial sodium channel
Alveolar fluid clearance
Peroxisome proliferator-activated receptor γ
Serum and glucocorticoid induced kinase-1
Online Access:http://link.springer.com/article/10.1186/s11658-019-0154-0

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http://link.springer.com/article/10.1186/s11658-019-0154-0

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