Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth

Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth

Changes in glucose metabolism can lead to tumor development, but the involvement of splicing factors is unclear. Here, the authors screened for SR proteins and identified SRSF5 stability is enhanced in response to glucose elevation to promote alternative splicing of CCAR1 which facilitates tumor gro...

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Bibliographic Details
Main Authors: Yuhan Chen, Qingyang Huang, Wen Liu, Qiong Zhu, Chun-Ping Cui, Liang Xu, Xing Guo, Ping Wang, Jingwen Liu, Guanglong Dong, Wenyi Wei, Cui Hua Liu, Zhichun Feng, Fuchu He, Lingqiang Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04815-3

Internet

https://doi.org/10.1038/s41467-018-04815-3

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