Persistent Activation of Calcium‐Sensing Receptor Suppresses Bone Turnover, Increases Microcracks, and Decreases Bone Strength

Persistent Activation of Calcium‐Sensing Receptor Suppresses Bone Turnover, Increases Microcracks, and Decreases Bone Strength

Abstract Activating mutations of calcium‐sensing receptor (CaSR) cause autosomal dominant hypocalcemia type 1 (ADH1). Patients with ADH1 exhibit similar features to patients with hypoparathyroidism, including reduced serum parathyroid hormone (PTH) and Ca with low bone turnover. Although persistent...

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Bibliographic Details
Main Authors: Bingzi Dong, Itsuro Endo, Yukiyo Ohnishi, Yukari Mitsui, Kiyoe Kurahashi, Mai Kanai, Masahiro Hiasa, Jumpei Teramachi, Hirofumi Tenshin, Seiji Fukumoto, Masahiro Abe, Toshio Matsumoto
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:JBMR Plus
Subjects:
CALCIUM‐SENSING RECEPTOR
MICROCRACK
ADH1
Online Access:https://doi.org/10.1002/jbm4.10182

Internet

https://doi.org/10.1002/jbm4.10182

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