Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells

Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells

Increased breast density attributed to collagen I deposition is associated with a 4–6 fold increased risk of developing breast cancer. Here, we assessed cellular metabolic reprogramming of mammary carcinoma cells in response to increased collagen matrix density using an in vitro 3D model. Our initia...

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Bibliographic Details
Main Authors: Brett A. Morris, Brian Burkel, Suzanne M. Ponik, Jing Fan, John S. Condeelis, Julio A. Aguire-Ghiso, James Castracane, John M. Denu, Patricia J. Keely
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:EBioMedicine
Subjects:
Collagen
Matrix density
Metabolism
Breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416304674

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http://www.sciencedirect.com/science/article/pii/S2352396416304674

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