Healing of a Large Long-Bone Defect through Serum-Free In Vitro Priming of Human Periosteum-Derived Cells

Healing of a Large Long-Bone Defect through Serum-Free In Vitro Priming of Human Periosteum-Derived Cells

Clinical translation of cell-based strategies for regenerative medicine demands predictable in vivo performance where the use of sera during in vitro preparation inherently limits the efficacy and reproducibility. Here, we present a bioinspired approach by serum-free pre-conditioning of human perios...

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Bibliographic Details
Main Authors: Johanna Bolander, Wei Ji, Jeroen Leijten, Liliana Moreira Teixeira, Veerle Bloemen, Dennis Lambrechts, Malay Chaklader, Frank P. Luyten
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Stem Cell Reports
Subjects:
stem cells
progenitor cells
bone morphogenetic proteins
fracture healing
critical bone fractures
fracture nonunion regenerative medicine
serum free
cell-based constructs
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117300206

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http://www.sciencedirect.com/science/article/pii/S2213671117300206

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