Choline Kinase: An Unexpected Journey for a Precision Medicine Strategy in Human Diseases

Choline Kinase: An Unexpected Journey for a Precision Medicine Strategy in Human Diseases

Choline kinase (ChoK) is a cytosolic enzyme that catalyzes the phosphorylation of choline to form phosphorylcholine (<i>P</i>Cho) in the presence of ATP and magnesium. ChoK is required for the synthesis of key membrane phospholipids and is involved in malignant transformation in a large...

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Bibliographic Details
Main Authors: Juan Carlos Lacal, Tahl Zimmerman, Joaquín M. Campos
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
phospholipids metabolism
choline kinase
bispyridinium compounds
bisquinolinium compounds
QSAR
anticancer drugs
Online Access:https://www.mdpi.com/1999-4923/13/6/788

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https://www.mdpi.com/1999-4923/13/6/788

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