Novel Mannitol-Based Small Molecules for Inhibiting Aggregation of α-Synuclein Amyloids in Parkinson's Disease

Novel Mannitol-Based Small Molecules for Inhibiting Aggregation of α-Synuclein Amyloids in Parkinson's Disease

The aggregation of the amyloidogenic protein α-synuclein (α-Syn) into toxic oligomers and mature fibrils is the major pathological hallmark of Parkinson's disease (PD). Small molecules that inhibit α-Syn aggregation thus may be useful therapeutics for PD. Mannitol and naphthoquinone-tryptophan...

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Bibliographic Details
Main Authors: Ashim Paul, Bo-Dou Zhang, Satabdee Mohapatra, Gao Li, Yan-Mei Li, Ehud Gazit, Daniel Segal
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
α-synuclein
Parkinson's disease
mannitol
NQTrp
aggregation
inhibitor
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2019.00016/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2019.00016/full

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