The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesions Alters Macrophage Populations and Mediates Pancreatic Tumorigenesis

The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesions Alters Macrophage Populations and Mediates Pancreatic Tumorigenesis

The contributions of the innate immune system to the development of pancreatic cancer are still ill defined. Inflammatory macrophages can initiate metaplasia of pancreatic acinar cells to a duct-like phenotype (acinar-to-ductal metaplasia [ADM]), which then gives rise to pancreatic intraepithelial n...

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Bibliographic Details
Main Authors: Geou-Yarh Liou, Ligia Bastea, Alicia Fleming, Heike Döppler, Brandy H. Edenfield, David W. Dawson, Lizhi Zhang, Nabeel Bardeesy, Peter Storz
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cell Reports
Subjects:
pancreatic cancer
PanIN
metaplasia
Tuft cells
macrophages
polarization
IL-13
interleukin-13
CCL-2
IL-1ra
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717305466

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http://www.sciencedirect.com/science/article/pii/S2211124717305466

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