Coating with flexible DNA network enhanced T-cell activation and tumor killing for adoptive cell therapy

Coating with flexible DNA network enhanced T-cell activation and tumor killing for adoptive cell therapy

Adoptive cell therapy (ACT) is an emerging powerful cancer immunotherapy, which includes a complex process of genetic modification, stimulation and expansion. During these in vitro or ex vivo manipulation, sensitive cells are inescapability subjected to harmful external stimuli. Although a variety o...

Full description

Bibliographic Details
Main Authors: Ziyan Zhang, Qiaojuan Liu, Jizhou Tan, Xiaoxia Zhan, Ting Liu, Yuting Wang, Gen Lu, Minhao Wu, Yuanqing Zhang
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Cell surface engineering
Selective cytoprotection
DNA nanostructure
Tetrahedral DNA nanostructure
Rolling circle amplification
Adoptive cell therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521001179

Internet

http://www.sciencedirect.com/science/article/pii/S2211383521001179

Similar Items