Epigenetic Targeting of Aberrant Transcriptional Modulation in Pancreatic Cancer

Epigenetic Targeting of Aberrant Transcriptional Modulation in Pancreatic Cancer

While the mortality rates of cancer are generally declining, pancreatic cancer persists to be an exception with a 5-year-survival rate of less than 7%. Late diagnosis and resistance to conventional therapies contribute to high mortality rates in spite of the remarkable recent advances in cancer mana...

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Bibliographic Details
Main Authors: Feda H. Hamdan, Steven A. Johnsen
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Epigenomes
Subjects:
Bromodomain and Extra-terminal (BET) inhibitors
histone deacetylase (HDAC) inhibitors
pancreatic cancer
aberrant transcription
enhancers
transcription factors
distal regulatory elements
MYC
Forkhead Box A1 (FOXA1)
Bromodomain containing protein 4 (BRD4)
Online Access:http://www.mdpi.com/2075-4655/2/2/8

Internet

http://www.mdpi.com/2075-4655/2/2/8

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