Metformin modifies glutamine metabolism in an in vitro and in vivo model of hepatic encephalopathy

Metformin modifies glutamine metabolism in an in vitro and in vivo model of hepatic encephalopathy

ABSTRACT Aim: to analyze the effect of metformin on ammonia production derived from glutamine metabolism in vitro and in vivo. Methods: twenty male Wistar rats were studied for 28 days after a porto-caval anastomosis (n = 16) or a sham operation (n = 4). Porto-caval shunted animals were randomized...

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Bibliographic Details
Main Authors: Antonio Gil-Gómez, Ana-Isabel Gómez-Sotelo, Isidora Ranchal, Ángela Rojas, Marta García-Valdecasas, Rocío Muñoz-Hernández, Rocío Gallego-Durán, Javier Ampuero, Manuel Romero-Gómez
Format: Article
Language:English
Published: Aran Ediciones
Series:Revista Espanola de Enfermedades Digestivas
Subjects:
Hepatic encephalopathy
Metformin
Ammonia
Glutaminase
Glutamine
Cirrhosis
ASCT2
mTOR
Porto-caval anastomosis
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