Absorption Characteristics of Combination Medication of Realgar and Indigo Naturalis: In Vitro Transport across MDCK-MDR1 Cells and In Vivo Pharmacokinetics in Mice after Oral Administration

Absorption Characteristics of Combination Medication of Realgar and Indigo Naturalis: In Vitro Transport across MDCK-MDR1 Cells and In Vivo Pharmacokinetics in Mice after Oral Administration

Realgar and indigo naturalis are clinically combined to treat varieties of leukemia. Exploring the drug-drug interactions might be beneficial to find active substances and develop new targeted drugs. This study aimed at exploring the change of arsenic concentration in mice and across MDCK-MDR1 cells...

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Bibliographic Details
Main Authors: Miao Zhang, Lin Guo, Long-Fei Lin, Chang-Hai Qu, Xing-Bin Yin, Shi-Lin Luo, Xin Zhang, Hai-Ying Zhang, Xiao Liang, Jun Guan, Jian Ni
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2018/6493630

Internet

http://dx.doi.org/10.1155/2018/6493630

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