Virtual Screening and Molecular Dynamics Study of Potential Negative Allosteric Modulators of mGluR1 from Chinese Herbs

Virtual Screening and Molecular Dynamics Study of Potential Negative Allosteric Modulators of mGluR1 from Chinese Herbs

The metabotropic glutamate subtype 1 (mGluR1), a member of the metabotropic glutamate receptors, is a therapeutic target for neurological disorders. However, due to the lower subtype selectivity of mGluR1 orthosteric compounds, a new targeted strategy, known as allosteric modulators research, is nee...

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Bibliographic Details
Main Authors: Ludi Jiang, Xianbao Zhang, Xi Chen, Yusu He, Liansheng Qiao, Yanling Zhang, Gongyu Li, Yuhong Xiang
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:Molecules
Subjects:
mGluR1
NAMs
virtual
pharmacophore
docking
MD
TCM
Online Access:http://www.mdpi.com/1420-3049/20/7/12769

Internet

http://www.mdpi.com/1420-3049/20/7/12769

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