Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design

Hyperpolarization methods play a crucial role in the in vivo observation of molecular metabolism by MRI techniques. Here, the authors develop NHC-containing iridium complexes which improve the NMR detectability of 1H, 13C and 15N nuclei via transfer of latent magnetism of para-hydrogen into a substr...

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Main Authors:	Peter J. Rayner, Philip Norcott, Kate M. Appleby, Wissam Iali, Richard O. John, Sam J. Hart, Adrian C. Whitwood, Simon B. Duckett
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-06766-1

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spelling	doaj-3fab6706f7ef444298fb209e56531a8d2021-05-11T10:21:06ZengNature Publishing GroupNature Communications2041-17232018-10-019111110.1038/s41467-018-06766-1Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene designPeter J. Rayner0Philip Norcott1Kate M. Appleby2Wissam Iali3Richard O. John4Sam J. Hart5Adrian C. Whitwood6Simon B. Duckett7Centre for Hyperpolarisation in Magnetic Resonance, Department of Chemistry, University of YorkCentre for Hyperpolarisation in Magnetic Resonance, Department of Chemistry, University of YorkCentre for Hyperpolarisation in Magnetic Resonance, Department of Chemistry, University of YorkCentre for Hyperpolarisation in Magnetic Resonance, Department of Chemistry, University of YorkCentre for Hyperpolarisation in Magnetic Resonance, Department of Chemistry, University of YorkCentre for Hyperpolarisation in Magnetic Resonance, Department of Chemistry, University of YorkCentre for Hyperpolarisation in Magnetic Resonance, Department of Chemistry, University of YorkCentre for Hyperpolarisation in Magnetic Resonance, Department of Chemistry, University of YorkHyperpolarization methods play a crucial role in the in vivo observation of molecular metabolism by MRI techniques. Here, the authors develop NHC-containing iridium complexes which improve the NMR detectability of 1H, 13C and 15N nuclei via transfer of latent magnetism of para-hydrogen into a substrate.https://doi.org/10.1038/s41467-018-06766-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Peter J. Rayner Philip Norcott Kate M. Appleby Wissam Iali Richard O. John Sam J. Hart Adrian C. Whitwood Simon B. Duckett
spellingShingle	Peter J. Rayner Philip Norcott Kate M. Appleby Wissam Iali Richard O. John Sam J. Hart Adrian C. Whitwood Simon B. Duckett Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design Nature Communications
author_facet	Peter J. Rayner Philip Norcott Kate M. Appleby Wissam Iali Richard O. John Sam J. Hart Adrian C. Whitwood Simon B. Duckett
author_sort	Peter J. Rayner
title	Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design
title_short	Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design
title_full	Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design
title_fullStr	Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design
title_full_unstemmed	Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design
title_sort	fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational n-heterocyclic carbene design
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-10-01
description	Hyperpolarization methods play a crucial role in the in vivo observation of molecular metabolism by MRI techniques. Here, the authors develop NHC-containing iridium complexes which improve the NMR detectability of 1H, 13C and 15N nuclei via transfer of latent magnetism of para-hydrogen into a substrate.
url	https://doi.org/10.1038/s41467-018-06766-1
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Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design

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