Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design

Hyperpolarization methods play a crucial role in the in vivo observation of molecular metabolism by MRI techniques. Here, the authors develop NHC-containing iridium complexes which improve the NMR detectability of 1H, 13C and 15N nuclei via transfer of latent magnetism of para-hydrogen into a substr...

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Bibliographic Details
Main Authors: Peter J. Rayner, Philip Norcott, Kate M. Appleby, Wissam Iali, Richard O. John, Sam J. Hart, Adrian C. Whitwood, Simon B. Duckett
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06766-1