Gabapentin Modulates HCN4 Channel Voltage-Dependence

Gabapentin Modulates HCN4 Channel Voltage-Dependence

Gabapentin (GBP) is widely used to treat epilepsy and neuropathic pain. There is evidence that GBP can act on hyperpolarization-activated cation (HCN) channel-mediated Ih in brain slice experiments. However, evidence showing that GBP directly modulates HCN channels is lacking. The effect of GBP was...

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Bibliographic Details
Main Authors: Han-Shen Tae, Kelly M. Smith, A. Marie Phillips, Kieran A. Boyle, Melody Li, Ian C. Forster, Robert J. Hatch, Robert Richardson, David I. Hughes, Brett A. Graham, Steven Petrou, Christopher A. Reid
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Pharmacology
Subjects:
HCN4
gabapentin
pain
epilepsy
spinal cord
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00554/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00554/full

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