G protein coupled estrogen receptor attenuates mechanical stress-mediated apoptosis of chondrocyte in osteoarthritis via suppression of Piezo1

G protein coupled estrogen receptor attenuates mechanical stress-mediated apoptosis of chondrocyte in osteoarthritis via suppression of Piezo1

Abstract Background Apoptosis of chondrocyte is involved in osteoarthritis (OA) pathogenesis, and mechanical stress plays a key role in this process by activation of Piezo1. However, the negative regulation of signal conduction mediated by mechanical stress is still unclear. Here, we elucidate that...

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Bibliographic Details
Main Authors: Yi Sun, Ping Leng, Pengcheng Guo, Huanshen Gao, Yikai Liu, Chenkai Li, Zhenghui Li, Haining Zhang
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Molecular Medicine
Subjects:
G protein coupled estrogen receptor
Osteoarthritis
Mechanical stress
Chondrocyte
Piezo1
Online Access:https://doi.org/10.1186/s10020-021-00360-w

Internet

https://doi.org/10.1186/s10020-021-00360-w

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