Dichlorodiphenyltrichloroethane Impairs Amyloid Beta Clearance by Decreasing Liver X Receptor α Expression

Dichlorodiphenyltrichloroethane Impairs Amyloid Beta Clearance by Decreasing Liver X Receptor α Expression

Abnormal amyloid beta (Aβ) clearance is a distinctive pathological mechanism for Alzheimer’s disease (AD). ATP-binding cassette transporter A1 (ABCA1), which mediates the lipidation of apolipoprotein E, plays a critical role in Aβ clearance. As an environmental factor for AD, dichlorodiphenyltrichlo...

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Bibliographic Details
Main Authors: Dongmei Wu, Yang Hu, Min Song, Gongbo Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
amyloid beta
dichlorodiphenyltrichloroethane
liver X receptor α
Alzheimer’s disease
ATP-binding cassette transporter A1
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.634948/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2021.634948/full

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