Modulation of the epithelial sodium channel (ENaC) by bacterial metalloproteases and protease inhibitors.

The serralysin family of metalloproteases is associated with the virulence of multiple gram-negative human pathogens, including Pseudomonas aeruginosa and Serratia marcescens. The serralysin proteases share highly conserved catalytic domains and show evolutionary similarity to the mammalian matrix m...

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Bibliographic Details
Main Authors: Michael B Butterworth, Liang Zhang, Xiaoning Liu, Robert M Shanks, Patrick H Thibodeau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4070987?pdf=render