Convergent Evolution by Cancer and Viruses in Evading the NKG2D Immune Response

Convergent Evolution by Cancer and Viruses in Evading the NKG2D Immune Response

The natural killer group 2 member D (NKG2D) receptor and its family of NKG2D ligands (NKG2DLs) are key components in the innate immune system, triggering NK, γδ and CD8<sup>+</sup> T cell-mediated immune responses. While surface NKG2DL are rarely found on healthy cells, expression is sig...

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Bibliographic Details
Main Authors: Richard Baugh, Hena Khalique, Leonard W. Seymour
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cancers
Subjects:
NKG2D ligands
NKG2D receptor
NK cells
immune evasion
convergent evolution
cancer
Online Access:https://www.mdpi.com/2072-6694/12/12/3827

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