Folding for the Immune Synapse: CCT Chaperonin and the Cytoskeleton

Lymphocytes rearrange their shape, membrane receptors and organelles during cognate contacts with antigen-presenting cells (APCs). Activation of T cells by APCs through pMHC-TCR/CD3 interaction (peptide-major histocompatibility complex-T cell receptor/CD3 complexes) involves different steps that lea...

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Bibliographic Details
Main Authors: Noa Beatriz Martín-Cófreces, José María Valpuesta, Francisco Sánchez-Madrid
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
CCT
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.658460/full