OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity
The mechanisms by which deubiquitinases modulate tumour progression are not fully understood. Here, the authors perform an RNAi screen and identify that the deubiquitinase OTUD5 suppresses cancer growth in a TRIM25 dependent manner, which in turn controls the expression of tumour suppressor protein,...
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Bibliographic Details
| Main Authors: |
Fangzhou Li,
Qianqian Sun,
Kun Liu,
Ling Zhang,
Ning Lin,
Kaiqiang You,
Mingwei Liu,
Ning Kon,
Feng Tian,
Zebin Mao,
Tingting Li,
Tanjun Tong,
Jun Qin,
Wei Gu,
Dawei Li,
Wenhui Zhao |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-08-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-17926-7
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