OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity

OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity

The mechanisms by which deubiquitinases modulate tumour progression are not fully understood. Here, the authors perform an RNAi screen and identify that the deubiquitinase OTUD5 suppresses cancer growth in a TRIM25 dependent manner, which in turn controls the expression of tumour suppressor protein,...

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Bibliographic Details
Main Authors: Fangzhou Li, Qianqian Sun, Kun Liu, Ling Zhang, Ning Lin, Kaiqiang You, Mingwei Liu, Ning Kon, Feng Tian, Zebin Mao, Tingting Li, Tanjun Tong, Jun Qin, Wei Gu, Dawei Li, Wenhui Zhao
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17926-7

Internet

https://doi.org/10.1038/s41467-020-17926-7

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