Anti-apoptotic effects of IGF-I on mortality and dysmorphogenesis in tbx5-deficient zebrafish embryos

Anti-apoptotic effects of IGF-I on mortality and dysmorphogenesis in tbx5-deficient zebrafish embryos

Abstract Background Tbx5 deficiency in zebrafish causes several abnormal phenotypes of the heart and pectoral fins. It has been reported that exogenous human growth hormone can enhance expression of downstream mediators in the growth hormone and insulin-like growth factor I (IGF-I) pathway and parti...

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Bibliographic Details
Main Authors: Tzu-Chun Tsai, Chun-Che Shih, Hsin-Ping Chien, An-Hang Yang, Jenn-Kan Lu, Jen-Her Lu
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Developmental Biology
Subjects:
Apoptosis
Holt-Oram syndrome
Insulin-like growth factor I
tbx5
Zebrafish
Online Access:http://link.springer.com/article/10.1186/s12861-017-0161-1

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http://link.springer.com/article/10.1186/s12861-017-0161-1

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