Overexpression of Indoleamine 2,3-Dioxygenase 1 Promotes Epithelial-Mesenchymal Transition by Activation of the IL-6/STAT3/PD-L1 Pathway in Bladder Cancer

Overexpression of Indoleamine 2,3-Dioxygenase 1 Promotes Epithelial-Mesenchymal Transition by Activation of the IL-6/STAT3/PD-L1 Pathway in Bladder Cancer

Indoleamine 2,3-dioxygenase 1 (IDO1) is a key enzyme in tryptophan metabolism and plays an important role in tumor cell immunosuppression and angiogenesis. The molecular mechanisms of IDO1 and epithelial-mesenchymal transition (EMT) have not been elucidated or studied in bladder cancer. Therefore, t...

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Bibliographic Details
Main Authors: Wentao Zhang, Junfeng Zhang, Ziwei Zhang, Yadong Guo, Yuan Wu, Ruiliang Wang, Longsheng Wang, Shiyu Mao, Xudong Yao
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S193652331830531X

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http://www.sciencedirect.com/science/article/pii/S193652331830531X

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