Spinal Interleukin-1β Inhibits Astrocyte Cytochrome P450c17 Expression Which Controls the Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain

Spinal Interleukin-1β Inhibits Astrocyte Cytochrome P450c17 Expression Which Controls the Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain

We have recently demonstrated that sciatic nerve injury increases the expression of spinal cytochrome P450c17, a key neurosteroidogenic enzyme, which plays a critical role in the development of peripheral neuropathic pain. However, the modulatory mechanisms responsible for the expression of spinal P...

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Bibliographic Details
Main Authors: Sheu-Ran Choi, Ho-Jae Han, Alvin J. Beitz, Jang-Hern Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
interleukin-1β
interleukin-1 receptor type 1
cytochrome P450c17
astrocytes
mechanical allodynia
neuropathic pain
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00153/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00153/full

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