Epstein-Barr virus BGLF4 kinase retards cellular S-phase progression and induces chromosomal abnormality.

Epstein-Barr virus (EBV) induces an uncoordinated S-phase-like cellular environment coupled with multiple prophase-like events in cells replicating the virus. The EBV encoded Ser/Thr kinase BGLF4 has been shown to induce premature chromosome condensation through activation of condensin and topoisome...

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Main Authors: Yu-Hsin Chang, Chung-Pei Lee, Mei-Tzu Su, Jiin-Tarng Wang, Jen-Yang Chen, Su-Fang Lin, Ching-Hwa Tsai, Min-Jei Hsieh, Kenzo Takada, Mei-Ru Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3387188?pdf=render