Deep sequencing of antiviral T-cell responses to HCMV and EBV in humans reveals a stable repertoire that is maintained for many years.

Deep sequencing of antiviral T-cell responses to HCMV and EBV in humans reveals a stable repertoire that is maintained for many years.

CD8(+) T-cell responses against latent viruses can cover considerable portions of the CD8(+) T-cell compartment for many decades, yet their initiation and maintenance remains poorly characterized in humans. A key question is whether the clonal repertoire that is raised during the initial antiviral r...

Full description

Bibliographic Details
Main Authors: P L Klarenbeek, E B M Remmerswaal, I J M ten Berge, M E Doorenspleet, B D C van Schaik, R E E Esveldt, S D Koch, A ten Brinke, A H C van Kampen, F J Bemelman, P P Tak, F Baas, N de Vries, R A W van Lier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3460621?pdf=render

Internet

http://europepmc.org/articles/PMC3460621?pdf=render

Similar Items