Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome

Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome

<p>Abstract</p> <p>Background</p> <p>A modest change in HIV-1 fitness can have a significant impact on viral quasispecies evolution and viral pathogenesis, transmission and disease progression. To determine the impact of immune escape mutations selected by cytotoxic T l...

Full description

Bibliographic Details
Main Authors: Song Hongshuo, Pavlicek Jeffrey W, Cai Fangping, Bhattacharya Tanmoy, Li Hui, Iyer Shilpa S, Bar Katharine J, Decker Julie M, Goonetilleke Nilu, Liu Michael KP, Berg Anna, Hora Bhavna, Drinker Mark S, Eudailey Josh, Pickeral Joy, Moody M, Ferrari Guido, McMichael Andrew, Perelson Alan S, Shaw George M, Hahn Beatrice H, Haynes Barton F, Gao Feng
Format: Article
Language:English
Published: BMC 2012-10-01
Series:Retrovirology
Subjects:
Human immunodeficiency virus type I
Viral fitness
Cytotoxic T lymphocytes
Immune escape mutation
Transmitted/founder virus
Mathematical model
Online Access:http://www.retrovirology.com/content/9/1/89

Internet

http://www.retrovirology.com/content/9/1/89

Similar Items