MEK1/2 Inhibition in Murine Heart and Aorta After Oral Administration of Refametinib Supplemented Drinking Water

MEK1/2 Inhibition in Murine Heart and Aorta After Oral Administration of Refametinib Supplemented Drinking Water

Upregulation of the RAS-RAF-MEK-ERK-MAPK pathway is involved in the development of several human tumors, aortic aneurysms, atherosclerosis, and cardiomyopathy. Refametinib, a highly selective MEK-inhibitor, has already shown antineoplastic activity in phase II trials. Furthermore, it showed potency...

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Bibliographic Details
Main Authors: Felke Steijns, Nathalie Bracke, Marjolijn Renard, Julie De Backer, Patrick Sips, Nathan Debunne, Evelien Wynendaele, Frederick Verbeke, Bart De Spiegeleer, Laurence Campens
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Pharmacology
Subjects:
refametinib (RDEA119
BAY 86-9766)
RAS-RAF-MEK-ERK-MAPK pathway
murine myocardium
murine aorta
drinking water
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01336/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01336/full

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