Exploring T Cell Reactivity to Gliadin in Young Children with Newly Diagnosed Celiac Disease
Class II major histocompatibility molecules confer disease risk in Celiac disease (CD) by presenting gliadin peptides to CD4 T cells in the small intestine. Deamidation of gliadin peptides by tissue transglutaminase creates immunogenic peptides presented by HLA-DQ2 and DQ8 molecules to activate pro...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2014-01-01
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| Series: | Autoimmune Diseases |
| Online Access: | http://dx.doi.org/10.1155/2014/927190 |