HTLV-1 Tax mutants that do not induce G<sub>1 </sub>arrest are disabled in activating the anaphase promoting complex
<p>Abstract</p> <p>HTLV-1 Tax is a potent activator of viral transcription and NF-κB. Recent data indicate that Tax activates the anaphase promoting complex/cyclosome (APC/C) ahead of schedule, causing premature degradation of cyclin A, cyclin B1, securin, and Skp2. Premature loss...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2007-05-01
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| Series: | Retrovirology |
| Online Access: | http://www.retrovirology.com/content/4/1/35 |