Impact of Q141K on the Transport of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors by ABCG2

Impact of Q141K on the Transport of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors by ABCG2

The ATP-binding cassette transporter ABCG2 is expressed in various organs, such as the small intestine, liver, and kidney, and influences the pharmacokinetics of drugs that are its substrates. ABCG2 is also expressed by cancer cells and mediates resistance to anticancer agents by promoting the efflu...

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Bibliographic Details
Main Authors: Yutaka Inoue, Takashi Morita, Mari Onozuka, Ken-ichi Saito, Kazumi Sano, Kazuhiko Hanada, Masami Kondo, Yoichi Nakamura, Tohru Kishino, Hiroshi Nakagawa, Yoji Ikegami
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cells
Subjects:
ABCG2
ATP-binding cassette transporters
multidrug resistance
single nucleotide polymorphism
tyrosine kinase inhibitor
Online Access:https://www.mdpi.com/2073-4409/8/7/763

Internet

https://www.mdpi.com/2073-4409/8/7/763

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