Forward genetic screen in Caenorhabditis elegans suggests F57A10.2 and acp-4 as suppressors of C9ORF72 related phenotypes

Forward genetic screen in Caenorhabditis elegans suggests F57A10.2 and acp-4 as suppressors of C9ORF72 related phenotypes

An abnormally expanded GGGGCC repeat in C9ORF72 is the most frequent causal mutation associated with amyotrophic lateral sclerosis (ALS) frontotemporal lobar degeneration (FTLD). Both gain-of-function (gf) and loss-of-function (lf) mechanisms have been involved in C9ORF72 related ALS FTLD. The gf m...

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Bibliographic Details
Main Authors: XIN WANG, Limin Hao, Taixiang Saur, Katelyn JOYAL, Ying Zhao, Desheng Zhai, Jie Li, Mochtar Pribadi, Giovanni Coppola, Bruce M Cohen, Edgar(Ned) A Buttner
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Amyotrophic Lateral Sclerosis
Caenorhabditis elegans
C9orf72
Acp2
VAPB
ALS-FTLD
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00113/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00113/full

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