Lissencephaly-1 is a context-dependent regulator of the human dynein complex

Lissencephaly-1 is a context-dependent regulator of the human dynein complex

The cytoplasmic dynein-1 (dynein) motor plays a central role in microtubule organisation and cargo transport. These functions are spatially regulated by association of dynein and its accessory complex dynactin with dynamic microtubule plus ends. Here, we elucidate in vitro the roles of dynactin, end...

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Bibliographic Details
Main Authors: Janina Baumbach, Andal Murthy, Mark A McClintock, Carly I Dix, Ruta Zalyte, Ha Thi Hoang, Simon L Bullock
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-04-01
Series:eLife
Subjects:
dynein
dynamic microtubules
lissencephaly-1
dynactin
EB1
cargo adaptor
Online Access:https://elifesciences.org/articles/21768

Internet

https://elifesciences.org/articles/21768

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