MUC1 positive, Kras and Pten driven mouse gynecologic tumors replicate human tumors and vary in survival and nuclear grade based on anatomical location.

MUC1 positive, Kras and Pten driven mouse gynecologic tumors replicate human tumors and vary in survival and nuclear grade based on anatomical location.

Activating mutations of Kras oncogene and deletions of Pten tumor suppressor gene play important roles in cancers of the female genital tract. We developed here new preclinical models for gynecologic cancers, using conditional (Cre-loxP) mice with floxed genetic alterations in Kras and Pten. The tri...

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Bibliographic Details
Main Authors: Tejas S Tirodkar, Raluca A Budiu, Esther Elishaev, Lixin Zhang, Jyothi T Mony, Joan Brozick, Robert P Edwards, Anda M Vlad
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4117479?pdf=render

Internet

http://europepmc.org/articles/PMC4117479?pdf=render

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