Building a Bridge between Chemotherapy and Immunotherapy in Malignant Pleural Mesothelioma: Investigating the Effect of Chemotherapy on Immune Checkpoint Expression

Building a Bridge between Chemotherapy and Immunotherapy in Malignant Pleural Mesothelioma: Investigating the Effect of Chemotherapy on Immune Checkpoint Expression

In light of the promising results of immune checkpoint blockade (ICPB) in malignant pleural mesothelioma (MPM), we investigated the effect of different chemotherapeutic agents on the expression of immune checkpoints (ICPs) in order to rationally design a good treatment schedule for their combination...

Full description

Bibliographic Details
Main Authors: Elly Marcq, Jonas RM Van Audenaerde, Jorrit De Waele, Julie Jacobs, Jinthe Van Loenhout, Glenn Cavents, Patrick Pauwels, Jan P van Meerbeeck, Evelien LJ Smits
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
chemotherapy
tumor microenvironment
mesothelioma
immune checkpoints
MPM
PD-1
PD-L1
TIM-3
LAG-3
Online Access:https://www.mdpi.com/1422-0067/20/17/4182

Internet

https://www.mdpi.com/1422-0067/20/17/4182

Similar Items