Synthesis and Evaluation of Novel Biased μ-Opioid-Receptor (μOR) Agonists

Synthesis and Evaluation of Novel Biased μ-Opioid-Receptor (μOR) Agonists

‘Biased’ ligands of G protein-coupled receptors (GPCRs) represent a type of promising analgesic with reduced on-target side effects. PZM21, a potent μ-opioid-receptor (μOR)-biased agonist with a new chemical scaffold compared to classic opioids, has been identified...

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Bibliographic Details
Main Authors: Mengjun Ma, Jialin Sun, Menghua Li, Zixing Yu, Jingchao Cheng, Bohua Zhong, Weiguo Shi
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Molecules
Subjects:
μOR-biased agonist
PZM21
Gi signaling pathway
β-arrestin-2 recruitment
structure–activity relationship
Online Access:http://www.mdpi.com/1420-3049/24/2/259

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http://www.mdpi.com/1420-3049/24/2/259

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