Testosterone therapy delays cardiomyocyte aging via an androgen receptor-independent pathway

Testosterone therapy delays cardiomyocyte aging via an androgen receptor-independent pathway

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The testicular feminized (Tfm) mouse carries a nonfunctional androgen receptor (AR) and reduced circulating testosterone levels. We used Tfm and castrated mice to determine whether testosterone modulates markers of aging in cardiomyocytes via its classic AR-dependent pathway or conversion to estradi...

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Bibliographic Details
Main Authors: L. Zhang, S.Z. Wu, Y.J. Ruan, L. Hong, X.W. Xing, W.Y. Lai
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2011-11-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Aging
Testosterone
Cardiomyocyte
Androgen receptor
Estradiol
Tfm mice
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001100007&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001100007&lng=en&tlng=en

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