Neurosteroids reduce social isolation-induced behavioral deficits: a proposed link with neurosteroid-mediated upregulation of BDNF expression

Neurosteroids reduce social isolation-induced behavioral deficits: a proposed link with neurosteroid-mediated upregulation of BDNF expression

The pharmacological action of SSRI antidepressants may include a normalization of the decreased brain levels of neurosteroids such as that of the progesterone metabolite allopregnanolone and that of the brain-derived neurotrophic factor (BDNF), which are decreased in patients with depression and PTS...

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Bibliographic Details
Main Authors: Mauricio Schüler Nin, Luis eMartinez, Fabio ePibiri, Marianela eNelson, Graziano ePinna
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-11-01
Series:Frontiers in Endocrinology
Subjects:
Anxiety Disorders
Social Isolation
BDNF
GABAA receptors
5a-reductase type I
aggressive behavior
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00073/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00073/full

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