In vivo Evidence for Partial Activation of Eosinophils via the Histamine H4-Receptor: Adoptive Transfer Experiments Using Eosinophils From H4R−/− and H4R+/+ Mice

In vivo Evidence for Partial Activation of Eosinophils via the Histamine H4-Receptor: Adoptive Transfer Experiments Using Eosinophils From H4R−/− and H4R+/+ Mice

Our previous in vitro studies revealed that histamine via histamine the H4-receptors (H4R), as compared to other stimuli, such as eotaxin or formylpeptides, rather partially activates eosinophilic granulocytes (eosinophils). In order to evaluate the H4R-mediated activation of eosinophils in vivo, we...

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Bibliographic Details
Main Authors: Bastian Schirmer, Luisa Bringmann, Roland Seifert, Detlef Neumann
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
experimental colitis
histamine H4 receptor
histamine
cytokines
inflammatory bowel diseases
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02119/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02119/full

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