High Glucose Induced Changes in Human VEC Phenotype in a 3D Hydrogel Derived From Cell-Free Native Aortic Root

High Glucose Induced Changes in Human VEC Phenotype in a 3D Hydrogel Derived From Cell-Free Native Aortic Root

Background: Valvular endothelial cells (VEC) have key roles in maintaining valvular integrity and homeostasis, and dysfunctional VEC are the initiators and major contributors to aortic valve disease in diabetes. Previous studies have shown that HG stimulated an inflammatory phenotype in VEC. Inflamm...

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Bibliographic Details
Main Authors: Sergiu Cecoltan, Letitia Ciortan, Razvan D. Macarie, Mihaela Vadana, Andreea C. Mihaila, Monica Tucureanu, Mihaela-Loredana Vlad, Ionel Droc, Mihaela Gherghiceanu, Agneta Simionescu, Dan Teodor Simionescu, Elena Butoi, Ileana Manduteanu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
3D-valve model
endothelin-1
endothelial to mesenchymal transition
high glucose
inflammation
valvular endothelial cells
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.714573/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2021.714573/full

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