SKP2 and OTUD1 govern non-proteolytic ubiquitination of YAP that promotes YAP nuclear localization and activity

SKP2 and OTUD1 govern non-proteolytic ubiquitination of YAP that promotes YAP nuclear localization and activity

Dysregulation of signaling pathways that control organ size, such as the AKT-mTOR and Hippo-YAP pathways, often leads to tumorigenesis and metastasis. The Hippo pathway effector YAP is a transcriptional co-activator overexpressed or activated in human tumors. Accumulating evidence has demonstrated t...

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Bibliographic Details
Main Authors: Fan Yao, Zhenna Xiao, Yutong Sun, Li Ma
Format: Article
Language:English
Published: Shared Science Publishers OG 2018-08-01
Series:Cell Stress
Subjects:
YAP
non-proteolytic ubiquitination
SKP2
OTUD1
Online Access:http://www.cell-stress.com/researcharticles/skp2-and-otud1-govern-non-proteolytic-ubiquitination-of-yap-that-promotes-yap-nuclear-localization-and-activity/

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http://www.cell-stress.com/researcharticles/skp2-and-otud1-govern-non-proteolytic-ubiquitination-of-yap-that-promotes-yap-nuclear-localization-and-activity/

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