MutScan: fast detection and visualization of target mutations by scanning FASTQ data

Abstract Background Some types of clinical genetic tests, such as cancer testing using circulating tumor DNA (ctDNA), require sensitive detection of known target mutations. However, conventional next-generation sequencing (NGS) data analysis pipelines typically involve different steps of filtering,...

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Bibliographic Details
Main Authors: Shifu Chen, Tanxiao Huang, Tiexiang Wen, Hong Li, Mingyan Xu, Jia Gu
Format: Article
Language:English
Published: BMC 2018-01-01
Series:BMC Bioinformatics
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12859-018-2024-6