Efficacy of a Combined Antiplatelet Therapy Is Not Affected by a Simultaneous Binding of Cangrelor and PSB 0777 to Albumin

Efficacy of a Combined Antiplatelet Therapy Is Not Affected by a Simultaneous Binding of Cangrelor and PSB 0777 to Albumin

Concurrent administration of two drugs may complicate the management of acute coronary syndromes: competitive drug displacement diminishes drug binding and alters drug pharmacodynamics. We investigated the interaction of two antiplatelet compounds (PSB 0777 and cangrelor) with human serum albumin (H...

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Bibliographic Details
Main Authors: Joanna Wzorek, Radosław Bednarek, Cezary Watala, Magdalena Boncler
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
human serum albumin
cangrelor
adenosine analogue
fluorescence spectroscopy
surface plasmon resonance
molecular modeling
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.638257/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.638257/full

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