Synergistic Chromatin-Modifying Treatments Reactivate Latent HIV and Decrease Migration of Multiple Host-Cell Types

Synergistic Chromatin-Modifying Treatments Reactivate Latent HIV and Decrease Migration of Multiple Host-Cell Types

Upon infection of its host cell, human immunodeficiency virus (HIV) establishes a quiescent and non-productive state capable of spontaneous reactivation. Diverse cell types harboring the provirus form a latent reservoir, constituting a major obstacle to curing HIV. Here, we investigate the effects o...

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Bibliographic Details
Main Authors: Alexandra Blanco, Tarun Mahajan, Robert A. Coronado, Kelly Ma, Dominic R. Demma, Roy D. Dar
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Viruses
Subjects:
human immunodeficiency virus
latency reversal
monocytes
T cells
chromatin modifier
LTR promoter
Online Access:https://www.mdpi.com/1999-4915/13/6/1097

Internet

https://www.mdpi.com/1999-4915/13/6/1097

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