Implementation of a Physiologically Based Pharmacokinetic Modeling Approach to Guide Optimal Dosing Regimens for Imatinib and Potential Drug Interactions in Paediatrics

Implementation of a Physiologically Based Pharmacokinetic Modeling Approach to Guide Optimal Dosing Regimens for Imatinib and Potential Drug Interactions in Paediatrics

Long-term use of imatinib is effective and well-tolerated in children with chronic myeloid leukaemia (CML) yet defining an optimal dosing regimen for imatinib in younger patients is a challenge. The potential interactions between imatinib and coadministered drugs in this “special” population also re...

Full description

Bibliographic Details
Main Authors: Jeffry Adiwidjaja, Alan V. Boddy, Andrew J. McLachlan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Pharmacology
Subjects:
imatinib
physiologically based pharmacokinetic (PBPK)
simulation
paediatrics
drug interactions
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01672/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01672/full

Similar Items