Increasing tPA activity in astrocytes induced by multipotent mesenchymal stromal cells facilitate neurite outgrowth after stroke in the mouse.

Increasing tPA activity in astrocytes induced by multipotent mesenchymal stromal cells facilitate neurite outgrowth after stroke in the mouse.

We demonstrate that tissue plasminogen activator (tPA) and its inhibitors contribute to neurite outgrowth in the central nervous system (CNS) after treatment of stroke with multipotent mesenchymal stromal cells (MSCs). In vivo, administration of MSCs to mice subjected to middle cerebral artery occlu...

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Bibliographic Details
Main Authors: Hongqi Xin, Yi Li, Li Hong Shen, Xianshuang Liu, Xinli Wang, Jing Zhang, Siamak Pourabdollah-Nejad D, Chunling Zhang, Li Zhang, Hao Jiang, Zheng Gang Zhang, Michael Chopp
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2815778?pdf=render

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http://europepmc.org/articles/PMC2815778?pdf=render

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